T cells drive immune activation and promote clearance of infections and cancer. However, their function can also provoke autoimmune and allergic inflammation. The immune system therefore employs a variety of suppressive mechanisms, known as immunoregulatory mechanisms, to restrain excessive T cell activation that would otherwise cause deleterious inflammation, or immunopathology following infection. Immunoregulatory mechanisms also suppress beneficial T cell responses against cancer, resulting in deleterious immunosuppression. Immunoregulatory mechanisms therefore function as ‘brakes’ on immune activation and have important consequences in infection, inflammation and cancer.
Our research aims to uncover the molecular and cellular mechanisms underpinning immunoregulation and cancer immunosuppression. Fundamental discovery in the field of immunoregulation will pave the way for new therapies aimed at manipulating immune function in patients with autoimmunity and cancer.
The laboratory uses cutting-edge molecular immunology, functional genomics and mouse genetics to enable discovery of novel host immunoregulatory mechanisms (see Research). We have a particular interest in the immunoregulatory mechanisms that control the differentiation and function of CD4+ and CD8+ conventional T cells and Foxp3+ regulatory T (Treg) cells. The laboratory, led by Dr Rahul Roychoudhuri, is located at the University of Cambridge Department of Pathology and works closely with collaborators within both the University and broader Cambridge immunology community. Our work benefits from access to the world-class research facilities of the University of Cambridge.
We are looking for passionate new PhD students, Postdocs, and Master’s students (more info)!
(For a full list see Publications)